A great deal of research has pointed to deleterious roles of metal ions in the development of\r\nAlzheimer''s disease. These include: i) the precipitation and aggregation of amyloid (A) peptides\r\nto form senile plaques and neurofibrillary tangles, and/or ii) the augmentation of oxidative stress by\r\nmetal ion mediated production and activation of hydrogen peroxide. The growing trend in\r\nnutraceutical intake is in part a result of the belief that they postpone the development of dementias\r\nsuch as Alzheimer''s disease. However, pathogenic events centred on metal ions are expected to\r\nbe aggravated by frequent nutraceutical intake. Novel therapeutic approaches centred on chelators\r\nwith specificity for copper and iron ions should be fully explored.
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